Description
Letrozole Tablets IP: Tablets of letrozole IP is a drug used to treat postmenopausal women who have breast cancer. Letrozole, the drug’s active component, is a member of the group of medications known as aromatase inhibitors.
Letrozole functions by preventing the enzyme aromatase from converting androgens (male hormones) into estrogen (female hormones) in the body. Letrozole, which blocks aromatase, lowers the body’s estrogen levels, which can aid in slowing or halting the development of hormone-sensitive breast cancer cells.
How it works
Letrozole is a medicine that is categorized as an aromatase inhibitor, a group of medications. It functions by lowering the body’s estrogen levels, which can aid in slowing or halting the growth of specific kinds of breast cancer cells that depend on estrogen to proliferate.
The enzyme aromatase in the body converts androgens (male hormones) into estrogen. Letrozole lowers the amount of estrogen produced by blocking the aromatase enzyme. The development of breast cancer cells that are sensitive to hormones may be slowed or stopped by this drop in estrogen.
How to use letrozole tablets
The usual dosage of letrozole pills is one oral dose per day, with or without meals. Depending on the patient’s medical history, the stage and type of breast cancer being treated, and other circumstances, the dose and length of the course of treatment may change.
It’s crucial to adhere to the dose recommendations given by a healthcare provider and avoid stopping letrozole abruptly without first talking to a doctor since this might have negative effects. Following are some general pointers for using letrozole tablets:
- Take your letrozole pills with or without meals at the same time every day.
- Do not chew, break, or crush the tablet; instead, swallow it whole with a glass of water.
- Take the missed dosage as soon as you recall it if you miss it.
- Skip the missed dosage and go on with your usual dosing plan if it is almost time for your next dose. To make up for a missing dosage, do not take a second one.
- When treating breast cancer, letrozole pills are commonly used for five years. When to quit taking letrozole and for how long will be determined by your doctor.
- Tablets containing letrozole may have unwanted symptoms, such as hot flashes, exhaustion, nausea, joint discomfort, and headaches. Speak with your doctor if you suffer any adverse effects or have any questions.
Who can benefit from Letrozole Tablets?
Only hormone receptor-positive breast cancer, which has estrogen or progesterone receptors on its surface, may be effectively treated with letrozole. Letrozole is unlikely to be beneficial in breast cancer situations when the hormone receptors are not active.
Usually, postmenopausal women with hormone receptor-positive breast cancer are treated with letrozole pills. It is significant to highlight that letrozole is not advised for usage in premenopausal, pregnant, or nursing women.
Fertility and letrozole
Because letrozole lowers the body’s estrogen levels, it may temporarily diminish women’s fertility. Becoming pregnant while using letrozole may be challenging.
Letrozole, however, can also be utilized by women undergoing reproductive treatments to trigger ovulation. Letrozole is frequently used in these situations in conjunction with other drugs to encourage ovulation.
It is crucial to talk to a healthcare professional about any fertility-related worries since they can advise you on the best course of action.
Negative effects
Letrozole side effects are possible, just as with any medicine. Hot flashes, tiredness, nausea, headaches, and joint discomfort, are some of the most typical letrozole side effects. Additionally, some women may report libido loss or dry vaginal skin.
Letrozole side effects that are less frequent include mood swings, difficulty sleeping, muscular discomfort, and bone pain. Speak to your doctor if you encounter any negative effects while taking letrozole. To control the adverse effects, they might be able to change the dosage or recommend different medicines.
It is significant to remember that letrozole may result in a loss of bone density, raising the risk of fractures. To monitor their bone density, letrozole-using women may be advised to take calcium and vitamin D supplements.
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